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Multiple published studies have tried to elucidate the answer

Some large database analyses have suggested a modest increase in pancreatitis risk, particularly in the first few months after initiation, while others have found no association after adjusting for confounding factors such as obesity, gallbladder disease, and alcohol use

Preparation of cigarette smoke extract CSE was prepared according to the previous study (Chen et al., 2009)

Also, the previous literature dominated by older trials from specific regions (mostly Europe), which may limit generalizability to other settings

Evasiveness or dismissiveness is a warning sign

The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide (GIP)